Research & Sources
The science behind your Stack.
Every recommendation we make is grounded in peer-reviewed research. Here are the studies, data, and clinical findings that inform our AI.
Key Findings
40%
of American adults are vitamin D deficient
Forrest & Stuhldreher, 2011
50%
of Americans don't get enough magnesium
DiNicolantonio et al., 2018
15:1
omega-6 to omega-3 ratio in Western diets (optimal is 2:1)
Simopoulos, 2002
25%
reduction in cardiovascular events from high-dose EPA
REDUCE-IT trial, Bhatt et al., 2019
0%
significant mortality benefit from generic multivitamins
USPSTF meta-analysis, 2022
Cited Research
65 peer-reviewed studies across 10 articles.
- 1
Multivitamin supplementation and mortality risk: meta-analyses of randomized controlled trials
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US dietary supplement market size and consumer trends
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International Society of Sports Nutrition position stand: creatine supplementation
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Sex-specific nutritional requirements and dietary supplement use
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Vitamin D deficiency prevalence by latitude and seasonal variation
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Calcium supplementation and cardiovascular risk: role of vitamin K2
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- 1
Subclinical magnesium deficiency: a principal driver of cardiovascular disease
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The effect of magnesium supplementation on primary insomnia in elderly
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Magnesium and exercise performance: muscle cramps and electrolyte losses
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The role of magnesium in neurological disorders and anxiety
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Magnesium in migraine prophylaxis: clinical evidence and recommendations
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Bioavailability of magnesium supplement forms: oxide vs citrate vs glycinate
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- 1
Prevalence and correlates of vitamin D deficiency in US adults
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Vitamin D: the sunshine vitamin and optimal serum levels
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Aging and vitamin D synthesis: reduced skin production in elderly
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Gao Q, et al. The association between vitamin D deficiency and sleep disorders: a systematic review and meta-analysis. Nutrients, 2018.
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Vitamin D supplementation to prevent acute respiratory infections: systematic review
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Vitamin K2 and calcium metabolism: synergy with vitamin D3
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- 1
Physicians’ Health Study II: multivitamins in the prevention of cancer and cardiovascular disease
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Women’s Health Initiative: multivitamin-mineral supplement use and chronic disease outcomes
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Personalized nutrition and dietary supplement use: evidence and recommendations
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Nutritional deficiency risk in vegetarian and vegan diets: systematic review
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Exercise-induced micronutrient demands: implications for supplementation
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Individual variation in micronutrient requirements: vitamin D, magnesium, and iron
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- 1
The importance of the omega-6/omega-3 fatty acid ratio in health and disease
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EPA supplementation and depression: systematic review and meta-analysis
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DHA and brain aging: role of docosahexaenoic acid in cognitive decline
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Conversion of ALA to EPA and DHA in humans: quantitative review
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REDUCE-IT trial: cardiovascular risk reduction with icosapent ethyl
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Oxidative quality of fish oil supplements: analysis of over-the-counter products
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- 1
Harvey LJ, et al. Impact of menstrual blood loss and diet on iron deficiency among women in the UK. British Journal of Nutrition, 2005.
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Pineda O, Ashmead HD. Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate. Nutrition, 2001.
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Liew SC, Gupta ED. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases. European Journal of Medical Genetics, 2015.
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Tian X, Diaz FJ. Acute dietary zinc deficiency before conception compromises oocyte epigenetic programming and disrupts embryonic development. Developmental Biology, 2013.
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Facchinetti F, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstetrics and Gynecology, 1991.
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Wyatt KM, et al. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ, 1999.
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Rahbar N, et al. Effect of omega-3 fatty acids on intensity of primary dysmenorrhea. International Journal of Gynaecology and Obstetrics, 2012.
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- 1
Park H, et al. A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients. Supportive Care in Cancer, 2011.
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Lee MS, et al. Maca (Lepidium meyenii) for treatment of menopausal symptoms: a systematic review. Maturitas, 2011.
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Bannai M, Kawai N. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. Journal of Pharmacological Sciences, 2012.
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Lucas M, et al. Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial. American Journal of Clinical Nutrition, 2009.
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Knapen MHJ, et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis International, 2013.
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Pottala JV, et al. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. Neurology, 2014.
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Meyer HE, et al. Vitamin D deficiency and secondary hyperparathyroidism and the association with bone mineral density in persons with Pakistani and Norwegian background living in Norway. Bone, 2004.
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- 1
De-Regil LM, et al. Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database of Systematic Reviews, 2015.
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Greenberg JA, et al. Folic acid supplementation and pregnancy: more than just neural tube defect prevention. Reviews in Obstetrics and Gynecology, 2011.
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Caudill MA, et al. Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study. FASEB Journal, 2018.
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Chiu YH, et al. Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction. Human Reproduction, 2018.
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Xu Y, et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reproductive Biology and Endocrinology, 2018.
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Chu J, et al. Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-analysis. Human Reproduction, 2018.
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Unfer V, et al. Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocrine Connections, 2017.
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- 1
Parazzini F, et al. Magnesium in the gynecological practice: a literature review. Magnesium Research, 2017.
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Proctor ML, Murphy PA. Herbal and dietary therapies for primary and secondary dysmenorrhoea. Cochrane Database of Systematic Reviews, 2001.
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Wyatt KM, et al. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ, 1999.
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Bertone-Johnson ER, Thys-Jacobs S, et al. Calcium and vitamin D intake and risk of incident premenstrual syndrome. Archives of Internal Medicine, 2005.
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Pruthi S, et al. Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study. Alternative Medicine Review, 2010.
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Yee BE, et al. Oral zinc supplementation for acne vulgaris: a systematic review and meta-analysis. PLOS ONE, 2020.
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Sohrabi N, et al. Evaluation of the effect of omega-3 fatty acids in the treatment of premenstrual syndrome. Complementary Therapies in Medicine, 2013.
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- 1
Milman N. Postpartum anemia I: definition, prevalence, causes, and consequences. Annals of Hematology, 2011.
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Hibbeln JR. Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. Journal of Affective Disorders, 2002.
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Wiedeman AM, et al. Dietary choline intake: current state of knowledge across the life cycle. Nutrients, 2018.
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Peppard L, et al. Association between vitamin B12 levels and depression in women at 6 months postpartum: a preliminary study. Nursing Research, 2020.
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Fernandes MFS, et al. Effect of omega-3 fatty acid supplementation on postpartum depression: a systematic review and meta-analysis. Journal of Affective Disorders, 2021.
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Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. Journal of Inflammation Research, 2018.
View on PubMed → - 7
Aghajafari F, et al. Vitamin D deficiency and antenatal and postpartum depression: a systematic review. Nutrients, 2018.
View on PubMed →
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