30% off first order

Research & Sources

The science behind your Stack.

Every recommendation we make is grounded in peer-reviewed research. Here are the studies, data, and clinical findings that inform our AI.

Key Findings

40%

of American adults are vitamin D deficient

Forrest & Stuhldreher, 2011

50%

of Americans don't get enough magnesium

DiNicolantonio et al., 2018

15:1

omega-6 to omega-3 ratio in Western diets (optimal is 2:1)

Simopoulos, 2002

25%

reduction in cardiovascular events from high-dose EPA

REDUCE-IT trial, Bhatt et al., 2019

0%

significant mortality benefit from generic multivitamins

USPSTF meta-analysis, 2022

Cited Research

65 peer-reviewed studies across 10 articles.

  1. 1

    Multivitamin supplementation and mortality risk: meta-analyses of randomized controlled trials

    View on PubMed →
  2. 2

    US dietary supplement market size and consumer trends

    View on PubMed →
  3. 3

    International Society of Sports Nutrition position stand: creatine supplementation

    View on PubMed →
  4. 4

    Sex-specific nutritional requirements and dietary supplement use

    View on PubMed →
  5. 5

    Vitamin D deficiency prevalence by latitude and seasonal variation

    View on PubMed →
  6. 6

    Calcium supplementation and cardiovascular risk: role of vitamin K2

    View on PubMed →
  1. 1

    Subclinical magnesium deficiency: a principal driver of cardiovascular disease

    View on PubMed →
  2. 2

    The effect of magnesium supplementation on primary insomnia in elderly

    View on PubMed →
  3. 3

    Magnesium and exercise performance: muscle cramps and electrolyte losses

    View on PubMed →
  4. 4

    The role of magnesium in neurological disorders and anxiety

    View on PubMed →
  5. 5

    Magnesium in migraine prophylaxis: clinical evidence and recommendations

    View on PubMed →
  6. 6

    Bioavailability of magnesium supplement forms: oxide vs citrate vs glycinate

    View on PubMed →
  1. 1

    Prevalence and correlates of vitamin D deficiency in US adults

    View on PubMed →
  2. 2

    Vitamin D: the sunshine vitamin and optimal serum levels

    View on PubMed →
  3. 3

    Aging and vitamin D synthesis: reduced skin production in elderly

    View on PubMed →
  4. 4

    Gao Q, et al. The association between vitamin D deficiency and sleep disorders: a systematic review and meta-analysis. Nutrients, 2018.

    View on PubMed →
  5. 5

    Vitamin D supplementation to prevent acute respiratory infections: systematic review

    View on PubMed →
  6. 6

    Vitamin K2 and calcium metabolism: synergy with vitamin D3

    View on PubMed →
  1. 1

    Physicians’ Health Study II: multivitamins in the prevention of cancer and cardiovascular disease

    View on PubMed →
  2. 2

    Women’s Health Initiative: multivitamin-mineral supplement use and chronic disease outcomes

    View on PubMed →
  3. 3

    Personalized nutrition and dietary supplement use: evidence and recommendations

    View on PubMed →
  4. 4

    Nutritional deficiency risk in vegetarian and vegan diets: systematic review

    View on PubMed →
  5. 5

    Exercise-induced micronutrient demands: implications for supplementation

    View on PubMed →
  6. 6

    Individual variation in micronutrient requirements: vitamin D, magnesium, and iron

    View on PubMed →
  1. 1

    The importance of the omega-6/omega-3 fatty acid ratio in health and disease

    View on PubMed →
  2. 2

    EPA supplementation and depression: systematic review and meta-analysis

    View on PubMed →
  3. 3

    DHA and brain aging: role of docosahexaenoic acid in cognitive decline

    View on PubMed →
  4. 4

    Conversion of ALA to EPA and DHA in humans: quantitative review

    View on PubMed →
  5. 5

    REDUCE-IT trial: cardiovascular risk reduction with icosapent ethyl

    View on PubMed →
  6. 6

    Oxidative quality of fish oil supplements: analysis of over-the-counter products

    View on PubMed →
  1. 1

    Harvey LJ, et al. Impact of menstrual blood loss and diet on iron deficiency among women in the UK. British Journal of Nutrition, 2005.

    View on PubMed →
  2. 2

    Pineda O, Ashmead HD. Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate. Nutrition, 2001.

    View on PubMed →
  3. 3

    Liew SC, Gupta ED. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases. European Journal of Medical Genetics, 2015.

    View on PubMed →
  4. 4

    Tian X, Diaz FJ. Acute dietary zinc deficiency before conception compromises oocyte epigenetic programming and disrupts embryonic development. Developmental Biology, 2013.

    View on PubMed →
  5. 5

    Facchinetti F, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstetrics and Gynecology, 1991.

    View on PubMed →
  6. 6

    Wyatt KM, et al. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ, 1999.

    View on PubMed →
  7. 7

    Rahbar N, et al. Effect of omega-3 fatty acids on intensity of primary dysmenorrhea. International Journal of Gynaecology and Obstetrics, 2012.

    View on PubMed →
  1. 1

    Park H, et al. A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients. Supportive Care in Cancer, 2011.

    View on PubMed →
  2. 2

    Lee MS, et al. Maca (Lepidium meyenii) for treatment of menopausal symptoms: a systematic review. Maturitas, 2011.

    View on PubMed →
  3. 3

    Bannai M, Kawai N. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. Journal of Pharmacological Sciences, 2012.

    View on PubMed →
  4. 4

    Lucas M, et al. Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial. American Journal of Clinical Nutrition, 2009.

    View on PubMed →
  5. 5

    Knapen MHJ, et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis International, 2013.

    View on PubMed →
  6. 6

    Pottala JV, et al. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. Neurology, 2014.

    View on PubMed →
  7. 7

    Meyer HE, et al. Vitamin D deficiency and secondary hyperparathyroidism and the association with bone mineral density in persons with Pakistani and Norwegian background living in Norway. Bone, 2004.

    View on PubMed →
  1. 1

    De-Regil LM, et al. Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database of Systematic Reviews, 2015.

    View on PubMed →
  2. 2

    Greenberg JA, et al. Folic acid supplementation and pregnancy: more than just neural tube defect prevention. Reviews in Obstetrics and Gynecology, 2011.

    View on PubMed →
  3. 3

    Caudill MA, et al. Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study. FASEB Journal, 2018.

    View on PubMed →
  4. 4

    Chiu YH, et al. Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction. Human Reproduction, 2018.

    View on PubMed →
  5. 5

    Xu Y, et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reproductive Biology and Endocrinology, 2018.

    View on PubMed →
  6. 6

    Chu J, et al. Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-analysis. Human Reproduction, 2018.

    View on PubMed →
  7. 7

    Unfer V, et al. Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocrine Connections, 2017.

    View on PubMed →
  1. 1

    Parazzini F, et al. Magnesium in the gynecological practice: a literature review. Magnesium Research, 2017.

    View on PubMed →
  2. 2

    Proctor ML, Murphy PA. Herbal and dietary therapies for primary and secondary dysmenorrhoea. Cochrane Database of Systematic Reviews, 2001.

    View on PubMed →
  3. 3

    Wyatt KM, et al. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ, 1999.

    View on PubMed →
  4. 4

    Bertone-Johnson ER, Thys-Jacobs S, et al. Calcium and vitamin D intake and risk of incident premenstrual syndrome. Archives of Internal Medicine, 2005.

    View on PubMed →
  5. 5

    Pruthi S, et al. Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study. Alternative Medicine Review, 2010.

    View on PubMed →
  6. 6

    Yee BE, et al. Oral zinc supplementation for acne vulgaris: a systematic review and meta-analysis. PLOS ONE, 2020.

    View on PubMed →
  7. 7

    Sohrabi N, et al. Evaluation of the effect of omega-3 fatty acids in the treatment of premenstrual syndrome. Complementary Therapies in Medicine, 2013.

    View on PubMed →
  1. 1

    Milman N. Postpartum anemia I: definition, prevalence, causes, and consequences. Annals of Hematology, 2011.

    View on PubMed →
  2. 2

    Hibbeln JR. Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. Journal of Affective Disorders, 2002.

    View on PubMed →
  3. 3

    Wiedeman AM, et al. Dietary choline intake: current state of knowledge across the life cycle. Nutrients, 2018.

    View on PubMed →
  4. 4

    Peppard L, et al. Association between vitamin B12 levels and depression in women at 6 months postpartum: a preliminary study. Nursing Research, 2020.

    View on PubMed →
  5. 5

    Fernandes MFS, et al. Effect of omega-3 fatty acid supplementation on postpartum depression: a systematic review and meta-analysis. Journal of Affective Disorders, 2021.

    View on PubMed →
  6. 6

    Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. Journal of Inflammation Research, 2018.

    View on PubMed →
  7. 7

    Aghajafari F, et al. Vitamin D deficiency and antenatal and postpartum depression: a systematic review. Nutrients, 2018.

    View on PubMed →

See what the research says about you.

Take the 2-minute health assessment and get a supplement stack backed by the studies above.

Take the Health Assessment